4P0F

Cleaved Serpin 42Da (C 2 2 21)

4P0F の概要

• エントリーDOI: 10.2210/pdb4p0f/pdb
• 分子名称: Serine protease inhibitor 4, isoform B (2 entities in total)
• 機能のキーワード: serpin 42da, serpin 4, serine protease inhibitor, neuroserpin, drosophila, hydrolase inhibitor
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44309.48

構造登録者

Ellisdon, A.M.,Whisstock, J.C. (登録日: 2014-02-21, 公開日: 2014-05-07, 最終更新日: 2023-09-27)

主引用文献

Ellisdon, A.M.,Zhang, Q.,Henstridge, M.A.,Johnson, T.K.,Warr, C.G.,Law, R.H.,Whisstock, J.C.
High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.
Bmc Struct.Biol., 14:14-14, 2014

PubMed Abstract: The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reactive centre loop exons. Eight protein isoforms of Serpin 42 Da have been identified to date, targeting the protease inhibitor to both different proteases and cellular locations. Biochemical and genetic studies suggest that Serpin 42 Da inhibits target proteases through the classical serpin 'suicide' inhibition mechanism, however the crystal structure of a representative Serpin 42 Da isoform remains to be determined.

PubMed: 24758516
DOI: 10.1186/1472-6807-14-14

実験手法

X-RAY DIFFRACTION (1.7 Å)