4P0C
Crystal Structure of NHERF2 PDZ1 Domain in Complex with LPA2
Summary for 4P0C
Entry DOI | 10.2210/pdb4p0c/pdb |
Descriptor | Na(+)/H(+) exchange regulatory cofactor NHE-RF2/Lysophosphatidic acid receptor 2 chimeric protein, THIOCYANATE ION, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | pdz, protein-protein interaction, protein binding |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell surface : Q9HBW0 |
Total number of polymer chains | 1 |
Total formula weight | 9930.15 |
Authors | Holcomb, J.,Jiang, Y.,Lu, G.,Trescott, L.,Brunzelle, J.,Sirinupong, N.,Li, C.,Naren, A.,Yang, Z. (deposition date: 2014-02-20, release date: 2014-05-21, Last modification date: 2024-03-27) |
Primary citation | Holcomb, J.,Jiang, Y.,Lu, G.,Trescott, L.,Brunzelle, J.,Sirinupong, N.,Li, C.,Naren, A.P.,Yang, Z. Structural insights into PDZ-mediated interaction of NHERF2 and LPA2, a cellular event implicated in CFTR channel regulation. Biochem.Biophys.Res.Commun., 446:399-403, 2014 Cited by PubMed: 24613836DOI: 10.1016/j.bbrc.2014.02.128 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.339 Å) |
Structure validation
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