4OVU
Crystal Structure of p110alpha in complex with niSH2 of p85alpha
Summary for 4OVU
Entry DOI | 10.2210/pdb4ovu/pdb |
Related | 4OVV |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (3 entities in total) |
Functional Keywords | p110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 4, 5 triphosphate, pip2, phosphatidylinositol 4, 5 bisphosphate, lipid kinase, phosphoinositide, 3-kinase, signaling, phosphatidylinositol 3-kinase, transferase-transferase regulator complex, transferase/transferase regulator |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 161489.54 |
Authors | Gabelli, S.B.,Vogelstein, B.,Miller, M.S.,Amzel, L.M. (deposition date: 2014-01-14, release date: 2014-09-03, Last modification date: 2023-09-27) |
Primary citation | Miller, M.S.,Schmidt-Kittler, O.,Bolduc, D.M.,Brower, E.T.,Chaves-Moreira, D.,Allaire, M.,Kinzler, K.W.,Jennings, I.G.,Thompson, P.E.,Cole, P.A.,Amzel, L.M.,Vogelstein, B.,Gabelli, S.B. Structural basis of nSH2 regulation and lipid binding in PI3K alpha. Oncotarget, 5:5198-5208, 2014 Cited by PubMed: 25105564PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.96 Å) |
Structure validation
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