4OU1

Crystal structure of a computationally designed retro-aldolase covalently bound to folding probe 1 [(6-methoxynaphthalen-2-yl)(oxiran-2-yl)methanol]

4OU1 の概要

• エントリーDOI: 10.2210/pdb4ou1/pdb
• 分子名称: Retro-aldolase, design RA114, (1S,2S)-1-(6-methoxynaphthalen-2-yl)propane-1,2-diol, BENZOIC ACID, ... (5 entities in total)
• 機能のキーワード: tim barrel, retro-aldolase, lyase
• 由来する生物種: Sulfolobus solfataricus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30341.55

構造登録者

Bhabha, G.,Zhang, X.,Ekiert, D.C. (登録日: 2014-02-14, 公開日: 2014-03-05, 最終更新日: 2023-09-20)

• 主引用文献: Liu, Y.,Tan, Y.L.,Zhang, X.,Bhabha, G.,Ekiert, D.C.,Genereux, J.C.,Cho, Y.,Kipnis, Y.,Bjelic, S.,Baker, D.,Kelly, J.W.; Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts.; Proc.Natl.Acad.Sci.USA, 111:4449-4454, 2014; PubMed: 24591605; DOI: 10.1073/pnas.1323268111

実験手法

X-RAY DIFFRACTION (1.25 Å)