4OTG

Crystal Structure of PRK1 Catalytic Domain in Complex with Lestaurtinib

4OTG の概要

• エントリーDOI: 10.2210/pdb4otg/pdb
• 関連するPDBエントリー: 4OTD 4OTH 4OTI
• 分子名称: Serine/threonine-protein kinase N1, Lestaurtinib (3 entities in total)
• 機能のキーワード: prk1, pkn1, protein kinase c related kinase 1, kinase, protein kinase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16512
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38780.97

構造登録者

Chamberlain, P.P.,Delker, S.,Pagarigan, B.,Mahmoudi, A.,Jackson, P.,Abbassian, M.,Muir, J.,Raheja, N.,Cathers, B. (登録日: 2014-02-13, 公開日: 2014-08-27, 最終更新日: 2022-12-07)

• 主引用文献: Chamberlain, P.,Delker, S.,Pagarigan, B.,Mahmoudi, A.,Jackson, P.,Abbasian, M.,Muir, J.,Raheja, N.,Cathers, B.; Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.; Plos One, 9:e103638-e103638, 2014; PubMed: 25111382; DOI: 10.1371/journal.pone.0103638

実験手法

X-RAY DIFFRACTION (2.6 Å)