4OT4

X-ray Structure of the Adduct formed between cisplatin and Ribonuclease A

4OT4 の概要

• エントリーDOI: 10.2210/pdb4ot4/pdb
• 関連するPDBエントリー: 1JVT
• 分子名称: Ribonuclease pancreatic, Cisplatin (3 entities in total)
• 機能のキーワード: rnase a fold, hydrolase
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28316.79

構造登録者

Messori, L.,Merlino, A. (登録日: 2014-02-13, 公開日: 2014-07-09, 最終更新日: 2023-09-20)

主引用文献

Messori, L.,Merlino, A.
Cisplatin binding to proteins: molecular structure of the ribonuclease a adduct.
Inorg.Chem., 53:3929-3931, 2014

PubMed Abstract: The crystal structure of the main adduct formed in the reaction between cisplatin and bovine pancreatic ribonuclease is reported here. Notably, in both of the protein molecules present in the asymmetric unit, platinum(II) binding takes place exclusively at the level of Met29. In one of the two molecules, the Gln28 side chain completes the platinum coordination sphere, anchoring the cisplatin fragment to the protein in a bidentate fashion. These results contain interesting implications for understanding the biological chemistry of this important drug.

PubMed: 24694179
DOI: 10.1021/ic500360f

実験手法

X-RAY DIFFRACTION (1.85 Å)