4OSO

The crystal structure of landomycin C-6 ketoreductase LanV with bound NADP and rabelomycin

Summary for 4OSO

Entry DOI	10.2210/pdb4oso/pdb
Related	4KWH 4KWI 4OSP
Descriptor	Reductase homolog, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, rabelomycin, ... (5 entities in total)
Functional Keywords	rossmann fold, ketoreductase, nadph binding, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic
Biological source	Streptomyces cyanogenus
Total number of polymer chains	2
Total formula weight	57377.82
Authors	Paananen, P.,Niiranen, L.,Patrikainen, P.,Metsa-Ketela, M. (deposition date: 2014-02-13, release date: 2014-10-01, Last modification date: 2023-09-20)
Primary citation	Patrikainen, P.,Niiranen, L.,Thapa, K.,Paananen, P.,Tahtinen, P.,Mantsala, P.,Niemi, J.,Metsa-Ketela, M. Structure-based engineering of angucyclinone 6-ketoreductases. Chem.Biol., 21:1381-1391, 2014 Cited by PubMed: 25200607 DOI: 10.1016/j.chembiol.2014.07.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation