4OP2
GKRP bound to AMG-0471 and Sorbitol-6-Phosphate
Summary for 4OP2
Entry DOI | 10.2210/pdb4op2/pdb |
Related | 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP3 |
Descriptor | Glucokinase Regulatory Protein, (2S)-2-{4'-[(6-aminopyridin-3-yl)sulfonyl]biphenyl-4-yl}-1,1,1-trifluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total) |
Functional Keywords | sis domain containing protein, binds to and inhibits glucokinase, glucokinase, carbohydrate binding protein-inhibitor complex, carbohydrate binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q14397 |
Total number of polymer chains | 2 |
Total formula weight | 145662.17 |
Authors | Jordan, S.R.,Chmait, S. (deposition date: 2014-02-04, release date: 2014-07-30, Last modification date: 2023-09-20) |
Primary citation | Tamayo, N.A.,Norman, M.H.,Bartberger, M.D.,Hong, F.T.,Bo, Y.,Liu, L.,Nishimura, N.,Yang, K.C.,Tadesse, S.,Fotsch, C.,Chen, J.,Chmait, S.,Cupples, R.,Hale, C.,Jordan, S.R.,Lloyd, D.J.,Sivits, G.,Van, G.,St Jean, D.J. Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis. J.Med.Chem., 58:4462-4482, 2015 Cited by PubMed: 25914941DOI: 10.1021/jm5018175 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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