4OOY

Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance

Summary for 4OOY

• Entry DOI: 10.2210/pdb4ooy/pdb
• Related: 4HEF
• Descriptor: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total)
• Functional Keywords: b-lactamase, carbamoylation with the inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa
• Cellular location: Periplasm : P24735
• Total number of polymer chains: 1
• Total formula weight: 39637.68

Authors

Lahiri, S.D.,Olivier, N.B.,Alm, R.A. (deposition date: 2014-02-04, release date: 2014-08-20, Last modification date: 2018-02-14)

• Primary citation: Lahiri, S.D.,Johnstone, M.R.,Ross, P.L.,McLaughlin, R.E.,Olivier, N.B.,Alm, R.A.; Avibactam and Class C beta-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance.; Antimicrob.Agents Chemother., 58:5704-5713, 2014; PubMed: 25022578; DOI: 10.1128/AAC.03057-14

Experimental method

X-RAY DIFFRACTION (1.1 Å)