4OOW

HCV NS5B polymerase with a fragment of quercetagetin

4OOW の概要

• エントリーDOI: 10.2210/pdb4oow/pdb
• 分子名称: RNA-directed RNA polymerase, CATECHOL (3 entities in total)
• 機能のキーワード: enzyme, transferase
• 由来する生物種: Hepatitis C virus (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129165.93

構造登録者

Guichou, J.F.,Ahmed-Belkacem, A.,Rozenn, B.,Nazim, N.,Hernandez, E.,Pallier, C.,Pawlotsky, J.M. (登録日: 2014-02-04, 公開日: 2014-12-17, 最終更新日: 2023-09-20)

• 主引用文献: Ahmed-Belkacem, A.,Guichou, J.F.,Brillet, R.,Ahnou, N.,Hernandez, E.,Pallier, C.,Pawlotsky, J.M.; Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention.; Nucleic Acids Res., 42:9399-9409, 2014; PubMed: 25053847; DOI: 10.1093/nar/gku632

実験手法

X-RAY DIFFRACTION (2.57 Å)