4OO9

Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant

Summary for 4OO9

• Entry DOI: 10.2210/pdb4oo9/pdb
• Descriptor: Metabotropic glutamate receptor 5, Lysozyme, Metabotropic glutamate receptor 5 chimera, OLEIC ACID, Mavoglurant, ... (5 entities in total)
• Functional Keywords: 7tm, receptor, g-protein, cysteine-s-acetamide, membrane protein
• Biological source: Homo sapiens (human, T4 phage, human); More
• Cellular location: Cell membrane {ECO:0000269|PubMed:7908515, ECO:0000269|Ref: P41594
• Total number of polymer chains: 1
• Total formula weight: 51555.11

Authors

Dore, A.S.,Okrasa, K.,Patel, J.C.,Serrano-Vega, M.,Bennett, K.,Cooke, R.M.,Errey, J.C.,Jazayeri, A.,Khan, S.,Tehan, B.,Weir, M.,Wiggin, G.R.,Marshall, F.H. (deposition date: 2014-01-31, release date: 2014-07-02, Last modification date: 2023-09-20)

• Primary citation: Dore, A.S.,Okrasa, K.,Patel, J.C.,Serrano-Vega, M.,Bennett, K.,Cooke, R.M.,Errey, J.C.,Jazayeri, A.,Khan, S.,Tehan, B.,Weir, M.,Wiggin, G.R.,Marshall, F.H.; Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.; Nature, 511:557-562, 2014; PubMed: 25042998; DOI: 10.1038/nature13396

Experimental method

X-RAY DIFFRACTION (2.6 Å)