4ON9

DECH box helicase domain

Summary for 4ON9

• Entry DOI: 10.2210/pdb4on9/pdb
• Descriptor: Probable ATP-dependent RNA helicase DDX58, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: pattern recognition receptor, cytosol, atpase, dech box domain, rna, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O95786
• Total number of polymer chains: 2
• Total formula weight: 132629.10

Authors

Deimling, T.,Witte, G.,Hopfner, K.P. (deposition date: 2014-01-28, release date: 2014-07-02, Last modification date: 2023-11-08)

Primary citation

Deimling, T.,Cui, S.,Lammens, K.,Hopfner, K.P.,Witte, G.
Crystal and solution structure of the human RIG-I SF2 domain
Acta Crystallogr.,Sect.F, 70:1027-1031, 2014

PubMed Abstract: RIG-I is a pathogen-recognition receptor that recognizes viral 5'-triphosphates carrying double-stranded RNA. Upon binding to these microbe-associated molecular patterns (MAMPs), RIG-I forms oligomers and promotes downstream processes that result in type I interferon production and induction of an antiviral state. Here, the crystal structure of the human RIG-I superfamily 2 ATPase domain crystallized in an unusually elongated and open conformation is reported. The elongated structure is probably induced in part by crystal packing, but nevertheless indicates that the domain is intrinsically very flexible. This flexibility might allow substantial structural changes upon substrate binding and oligomerization.

PubMed: 25084375
DOI: 10.1107/S2053230X14012230

Experimental method

X-RAY DIFFRACTION (2.71 Å)