4OLY

Crystal structure of antibody VRC07-G54R in complex with clade A/E 93TH057 HIV-1 gp120 core

Summary for 4OLY

• Entry DOI: 10.2210/pdb4oly/pdb
• Related: 4OLU 4OLV 4OLW 4OLX 4OLZ 4OM0 4OM1
• Descriptor: Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ... (5 entities in total)
• Functional Keywords: vrc07 antibody, passive transfer, neutralization, in vivo protection, autoreactivity, lentiviral infection, enhanced potency, hiv-1 gp120, vrc07-g54r, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 89437.31

Authors

Kwon, Y.D.,Kwong, P.D. (deposition date: 2014-01-25, release date: 2014-09-03, Last modification date: 2023-09-20)

• Primary citation: Rudicell, R.S.,Kwon, Y.D.,Ko, S.Y.,Pegu, A.,Louder, M.K.,Georgiev, I.S.,Wu, X.,Zhu, J.,Boyington, J.C.,Chen, X.,Shi, W.,Yang, Z.Y.,Doria-Rose, N.A.,McKee, K.,O'Dell, S.,Schmidt, S.D.,Chuang, G.Y.,Druz, A.,Soto, C.,Yang, Y.,Zhang, B.,Zhou, T.,Todd, J.P.,Lloyd, K.E.,Eudailey, J.,Roberts, K.E.,Donald, B.R.,Bailer, R.T.,Ledgerwood, J.,Mullikin, J.C.,Shapiro, L.,Koup, R.A.,Graham, B.S.,Nason, M.C.,Connors, M.,Haynes, B.F.,Rao, S.S.,Roederer, M.,Kwong, P.D.,Mascola, J.R.,Nabel, G.J.; Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.; J.Virol., 88:12669-12682, 2014; PubMed: 25142607; DOI: 10.1128/JVI.02213-14

Experimental method

X-RAY DIFFRACTION (2.351 Å)