4OIQ
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin
Summary for 4OIQ
Entry DOI | 10.2210/pdb4oiq/pdb |
Related | 4OIN 4OIO 4OIP 4OIR |
Related PRD ID | PRD_001181 |
Descriptor | DNA-directed RNA polymerase subunit alpha, MAGNESIUM ION, (2Z)-2-methylbut-2-enoic acid, ... (12 entities in total) |
Functional Keywords | ge23077, transcription inhibitor, transcription open complex, transcription initiation complex, i site, i+1 site, rifampicin, rif, rifampin, rna polymerase, dna/rna/ntp binding, polymerization of ribonucleotides, nucleoid, transcription, transferase-antibiotic complex, transferase/antibiotic |
Biological source | Thermus thermophilus More |
Cellular location | Cytoplasm (By similarity): Q5SKW1 |
Total number of polymer chains | 9 |
Total formula weight | 444818.42 |
Authors | Zhang, Y.,Ebright, R.H.,Arnold, E. (deposition date: 2014-01-20, release date: 2014-05-07, Last modification date: 2023-09-20) |
Primary citation | Zhang, Y.,Degen, D.,Ho, M.X.,Sineva, E.,Ebright, K.Y.,Ebright, Y.W.,Mekler, V.,Vahedian-Movahed, H.,Feng, Y.,Yin, R.,Tuske, S.,Irschik, H.,Jansen, R.,Maffioli, S.,Donadio, S.,Arnold, E.,Ebright, R.H. GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3:e02450-e02450, 2014 Cited by PubMed: 24755292PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.624 Å) |
Structure validation
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