4OHM

Human GKRP bound to AMG-0771 and sorbitol-6-phosphate

4OHM の概要

• エントリーDOI: 10.2210/pdb4ohm/pdb
• 関連するPDBエントリー: 4OHK 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3
• 分子名称: Glucokinase regulatory protein, (2S)-2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-3,3,3-trifluoropropane-1,2-diol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: sis domain containing protein, binds and inhibits glucokinase, glucokinase, liver, carbohydrate binding protein-inhibitor complex, carbohydrate binding protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q14397
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 145532.50

構造登録者

Jordan, S.R.,Chmait, S. (登録日: 2014-01-17, 公開日: 2014-07-30, 最終更新日: 2023-09-20)

• 主引用文献: Nishimura, N.,Norman, M.H.,Liu, L.,Yang, K.C.,Ashton, K.S.,Bartberger, M.D.,Chmait, S.,Chen, J.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kunz, R.K.,Pennington, L.D.,Poon, S.F.,Siegmund, A.,Sivits, G.,Lloyd, D.J.,Hale, C.,St Jean, D.J.; Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.; J.Med.Chem., 57:3094-3116, 2014; PubMed: 24611879; DOI: 10.1021/jm5000497

実験手法

X-RAY DIFFRACTION (2.4 Å)