4OGT

Co-Crystal Structure of MDM2 with Inhbitor Compound 46

4OGT の概要

• エントリーDOI: 10.2210/pdb4ogt/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, 6-{[(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: p53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12800.76

構造登録者

Shaffer, P.L.,Huang, X.,Yakowec, P.,Long, A.M. (登録日: 2014-01-16, 公開日: 2014-04-02, 最終更新日: 2023-09-20)

• 主引用文献: Gonzalez, A.Z.,Li, Z.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Duquette, J.,Eksterowicz, J.,Fox, B.M.,Fu, J.,Huang, X.,Houze, J.,Jin, L.,Li, Y.,Ling, Y.,Lo, M.C.,Long, A.M.,McGee, L.R.,McIntosh, J.,Oliner, J.D.,Osgood, T.,Rew, Y.,Saiki, A.Y.,Shaffer, P.,Wortman, S.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Olson, S.H.,Sun, D.,Medina, J.C.; Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.; J.Med.Chem., 57:2963-2988, 2014; PubMed: 24601644; DOI: 10.1021/jm401911v

実験手法

X-RAY DIFFRACTION (1.5361 Å)