4OGJ
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348
Summary for 4OGJ
Entry DOI | 10.2210/pdb4ogj/pdb |
Related | 4OGI |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | bromodomain, bromodomain containing protein 4, jak2 kinase inhibitor, flt3 kinase inhibitor, structural genomics, structural genomics consortium, sgc, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 31434.32 |
Authors | Filippakopoulos, P.,Picaud, S.,Jose, B.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-01-16, release date: 2014-02-26, Last modification date: 2023-09-20) |
Primary citation | Ciceri, P.,Muller, S.,O'Mahony, A.,Fedorov, O.,Filippakopoulos, P.,Hunt, J.P.,Lasater, E.A.,Pallares, G.,Picaud, S.,Wells, C.,Martin, S.,Wodicka, L.M.,Shah, N.P.,Treiber, D.K.,Knapp, S. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat.Chem.Biol., 10:305-312, 2014 Cited by PubMed: 24584101DOI: 10.1038/nchembio.1471 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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