4OGJ

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348

4OGJ の概要

• エントリーDOI: 10.2210/pdb4ogj/pdb
• 関連するPDBエントリー: 4OGI
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: bromodomain, bromodomain containing protein 4, jak2 kinase inhibitor, flt3 kinase inhibitor, structural genomics, structural genomics consortium, sgc, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31434.32

構造登録者

Filippakopoulos, P.,Picaud, S.,Jose, B.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2014-01-16, 公開日: 2014-02-26, 最終更新日: 2023-09-20)

• 主引用文献: Ciceri, P.,Muller, S.,O'Mahony, A.,Fedorov, O.,Filippakopoulos, P.,Hunt, J.P.,Lasater, E.A.,Pallares, G.,Picaud, S.,Wells, C.,Martin, S.,Wodicka, L.M.,Shah, N.P.,Treiber, D.K.,Knapp, S.; Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.; Nat.Chem.Biol., 10:305-312, 2014; PubMed: 24584101; DOI: 10.1038/nchembio.1471

実験手法

X-RAY DIFFRACTION (1.65 Å)