4OFZ

Structure of unliganded trehalose-6-phosphate phosphatase from Brugia malayi

Summary for 4OFZ

• Entry DOI: 10.2210/pdb4ofz/pdb
• Descriptor: Trehalose-phosphatase, MAGNESIUM ION (3 entities in total)
• Functional Keywords: had superfamily/rossmann fold, trehalose-6-phosphate phosphohydrolase, hydrolase
• Biological source: Brugia malayi (agent of lymphatic filariasis)
• Total number of polymer chains: 1
• Total formula weight: 57681.60

Authors

Farelli, J.D.,Allen, K.N.,Carlow, C.K.S.,Dunaway-Mariano, D. (deposition date: 2014-01-15, release date: 2014-07-16, Last modification date: 2018-01-24)

• Primary citation: Farelli, J.D.,Galvin, B.D.,Li, Z.,Liu, C.,Aono, M.,Garland, M.,Hallett, O.E.,Causey, T.B.,Ali-Reynolds, A.,Saltzberg, D.J.,Carlow, C.K.,Dunaway-Mariano, D.,Allen, K.N.; Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs.; Plos Pathog., 10:e1004245-e1004245, 2014; PubMed: 24992307; DOI: 10.1371/journal.ppat.1004245

Experimental method

X-RAY DIFFRACTION (3 Å)