4OD2
Crystal structure of the Fab fragment of an anti-DR5 antibody bound to DR5
Summary for 4OD2
Entry DOI | 10.2210/pdb4od2/pdb |
Related | 1d0g |
Descriptor | Fab fragment of drozitumab, light chain, Fab fragment of drozitumab, heavy chain, Tumor necrosis factor receptor superfamily member 10B (3 entities in total) |
Functional Keywords | igg, fab fragment, crd, tnfsf, apoptosis-immune system complex, apoptosis/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: O14763 |
Total number of polymer chains | 3 |
Total formula weight | 59358.91 |
Authors | Hymowitz, S.G.,Compaan, D. (deposition date: 2014-01-09, release date: 2014-02-05, Last modification date: 2023-09-20) |
Primary citation | Adams, C.,Totpal, K.,Lawrence, D.,Marsters, S.,Pitti, R.,Yee, S.,Ross, S.,Deforge, L.,Koeppen, H.,Sagolla, M.,Compaan, D.,Lowman, H.,Hymowitz, S.,Ashkenazi, A. Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5. Cell Death Differ., 15:751-761, 2008 Cited by PubMed: 18219321DOI: 10.1038/sj.cdd.4402306 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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