4OC6

Structure of Cathepsin D with inhibitor 2-bromo-N-[(2S,3S)-4-{[2-(2,4-dichlorophenyl)ethyl][3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino}-3-hydroxy-1-(3-phenoxyphenyl)butan-2-yl]-4,5-dimethoxybenzamide

4OC6 の概要

• エントリーDOI: 10.2210/pdb4oc6/pdb
• 関連するPDBエントリー: 1LYA 4OBZ 4OD9
• 分子名称: Cathepsin D light chain, Cathepsin D heavy chain, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: lysosomal aspartic protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39765.72

構造登録者

Graedler, U.,Czodrowski, P.,Tsaklakidis, C.,Klein, M.,Maskos, K.,Leuthner, B. (登録日: 2014-01-08, 公開日: 2014-08-13, 最終更新日: 2020-07-29)

• 主引用文献: Gradler, U.,Czodrowski, P.,Tsaklakidis, C.,Klein, M.,Werkmann, D.,Lindemann, S.,Maskos, K.,Leuthner, B.; Structure-based optimization of non-peptidic Cathepsin D inhibitors.; Bioorg.Med.Chem.Lett., 24:4141-4150, 2014; PubMed: 25086681; DOI: 10.1016/j.bmcl.2014.07.054

実験手法

X-RAY DIFFRACTION (2.64 Å)