4OC2
X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CEIBzL, a urea-based inhibitor N~2~-{[(1S)-1-carboxybut-3-yn-1-yl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine
Summary for 4OC2
Entry DOI | 10.2210/pdb4oc2/pdb |
Related | 4OC0 4OC1 4OC3 4OC4 4OC5 |
Descriptor | Glutamate carboxypeptidase 2, CHLORIDE ION, N~2~-{[(1S)-1-carboxybut-3-yn-1-yl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine, ... (12 entities in total) |
Functional Keywords | hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 83720.61 |
Authors | Pavlicek, J.,Ptacek, J.,Cerny, J.,Byun, Y.,Skultetyova, L.,Pomper, M.,Lubkowski, J.,Barinka, C. (deposition date: 2014-01-08, release date: 2014-05-21, Last modification date: 2020-07-29) |
Primary citation | Pavlicek, J.,Ptacek, J.,Cerny, J.,Byun, Y.,Skultetyova, L.,Pomper, M.G.,Lubkowski, J.,Barinka, C. Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24:2340-2345, 2014 Cited by PubMed: 24731280DOI: 10.1016/j.bmcl.2014.03.066 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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