4OBP
MAP4K4 in complex with inhibitor (compound 29), 6-(2-FLUOROPYRIDIN-4-YL)PYRIDO[3,2-D]PYRIMIDIN-4-AMINE
Summary for 4OBP
Entry DOI | 10.2210/pdb4obp/pdb |
Related | 4OBO 4OBQ |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 4, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : O95819 |
Total number of polymer chains | 2 |
Total formula weight | 76200.92 |
Authors | Harris, S.F.,Wu, P. (deposition date: 2014-01-07, release date: 2014-04-23, Last modification date: 2024-02-28) |
Primary citation | Crawford, T.D.,Ndubaku, C.O.,Chen, H.,Boggs, J.W.,Bravo, B.J.,Delatorre, K.,Giannetti, A.M.,Gould, S.E.,Harris, S.F.,Magnuson, S.R.,McNamara, E.,Murray, L.J.,Nonomiya, J.,Sambrone, A.,Schmidt, S.,Smyczek, T.,Stanley, M.,Vitorino, P.,Wang, L.,West, K.,Wu, P.,Ye, W. Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization. J.Med.Chem., 57:3484-3493, 2014 Cited by PubMed: 24673130DOI: 10.1021/jm500155b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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