4OBJ
Crystal Structure of Inactive HIV-1 Protease in Complex with the p1-p6 substrate variant (S451N)
Summary for 4OBJ
Entry DOI | 10.2210/pdb4obj/pdb |
Related | 4OBD 4OBF 4OBG 4OBH 4OBK |
Descriptor | HIV-1 Protease, p1-p6 peptide, GLYCEROL, ... (6 entities in total) |
Functional Keywords | co-evolution, resistance, hydrolase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 Gag polyprotein: Host cell membrane ; Lipid-anchor . Matrix protein p17: Virion membrane ; Lipid-anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion : P03349 |
Total number of polymer chains | 3 |
Total formula weight | 23655.78 |
Authors | Kolli, M. (deposition date: 2014-01-07, release date: 2014-11-26, Last modification date: 2023-09-20) |
Primary citation | Kolli, M.,Ozen, A.,Kurt-Yilmaz, N.,Schiffer, C.A. HIV-1 protease-substrate coevolution in nelfinavir resistance. J.Virol., 88:7145-7154, 2014 Cited by PubMed: 24719428DOI: 10.1128/JVI.00266-14 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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