4OBA
Co-crystal structure of MDM2 with Inhibitor Compound 4
Summary for 4OBA
Entry DOI | 10.2210/pdb4oba/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid (3 entities in total) |
Functional Keywords | p53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 3 |
Total formula weight | 35173.68 |
Authors | Shaffer, P.L.,Huang, X.,Yakowec, P.,Long, A.M. (deposition date: 2014-01-07, release date: 2014-03-19, Last modification date: 2023-09-20) |
Primary citation | Gonzalez, A.Z.,Eksterowicz, J.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Duquette, J.,Fox, B.M.,Fu, J.,Huang, X.,Houze, J.B.,Jin, L.,Li, Y.,Li, Z.,Ling, Y.,Lo, M.C.,Long, A.M.,McGee, L.R.,McIntosh, J.,McMinn, D.L.,Oliner, J.D.,Osgood, T.,Rew, Y.,Saiki, A.Y.,Shaffer, P.,Wortman, S.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Olson, S.H.,Medina, J.C.,Sun, D. Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 57:2472-2488, 2014 Cited by PubMed: 24548297DOI: 10.1021/jm401767k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.602 Å) |
Structure validation
Download full validation report