4OBA

Co-crystal structure of MDM2 with Inhibitor Compound 4

4OBA の概要

• エントリーDOI: 10.2210/pdb4oba/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid (3 entities in total)
• 機能のキーワード: p53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35173.68

構造登録者

Shaffer, P.L.,Huang, X.,Yakowec, P.,Long, A.M. (登録日: 2014-01-07, 公開日: 2014-03-19, 最終更新日: 2023-09-20)

• 主引用文献: Gonzalez, A.Z.,Eksterowicz, J.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Duquette, J.,Fox, B.M.,Fu, J.,Huang, X.,Houze, J.B.,Jin, L.,Li, Y.,Li, Z.,Ling, Y.,Lo, M.C.,Long, A.M.,McGee, L.R.,McIntosh, J.,McMinn, D.L.,Oliner, J.D.,Osgood, T.,Rew, Y.,Saiki, A.Y.,Shaffer, P.,Wortman, S.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Olson, S.H.,Medina, J.C.,Sun, D.; Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction.; J.Med.Chem., 57:2472-2488, 2014; PubMed: 24548297; DOI: 10.1021/jm401767k

実験手法

X-RAY DIFFRACTION (1.602 Å)