4OA7

Crystal structure of Tankyrase1 in complex with IWR1

Summary for 4OA7

• Entry DOI: 10.2210/pdb4oa7/pdb
• Descriptor: Tankyrase-1, ZINC ION, 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide, ... (4 entities in total)
• Functional Keywords: tankyrase, inhibitor, iwr1, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O95271
• Total number of polymer chains: 4
• Total formula weight: 100046.89

Authors

Zhang, X.,He, H. (deposition date: 2014-01-03, release date: 2015-01-07, Last modification date: 2023-09-20)

• Primary citation: Kulak, O.,Chen, H.,Holohan, B.,Wu, X.,He, H.,Borek, D.,Otwinowski, Z.,Yamaguchi, K.,Garofalo, L.A.,Ma, Z.,Wright, W.,Chen, C.,Shay, J.W.,Zhang, X.,Lum, L.; Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.; Mol.Cell.Biol., 35:2425-2435, 2015; PubMed: 25939383; DOI: 10.1128/MCB.00392-15

Experimental method

X-RAY DIFFRACTION (2.301 Å)