4O97

Crystal structure of matriptase in complex with inhibitor

4O97 の概要

• エントリーDOI: 10.2210/pdb4o97/pdb
• 関連するPDBエントリー: 4O9V
• 分子名称: Suppressor of tumorigenicity 14 protein, Peptide CGLR, N-(trans-4-aminocyclohexyl)-3,5-bis[(3-carbamimidoylbenzyl)oxy]benzamide, ... (4 entities in total)
• 機能のキーワード: matriptase, trypsin-like serine proteinase fold, protease, small molecule inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type II membrane protein (Probable): Q9Y5Y6 Q9Y5Y6
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27426.94

構造登録者

Rao, K.N.,Chandra, B.R.,Ashok, K.N.,Chakshusmathi, G.,Ramesh, K.S.,Subramanya, H.S. (登録日: 2014-01-02, 公開日: 2014-05-28, 最終更新日: 2023-11-08)

• 主引用文献: Goswami, R.,Mukherjee, S.,Ghadiyaram, C.,Wohlfahrt, G.,Sistla, R.K.,Nagaraj, J.,Satyam, L.K.,Subbarao, K.,Palakurthy, R.K.,Gopinath, S.,Krishnamurthy, N.R.,Ikonen, T.,Moilanen, A.,Subramanya, H.S.,Kallio, P.,Ramachandra, M.; Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.; Bioorg.Med.Chem., 22:3187-3203, 2014; PubMed: 24794746; DOI: 10.1016/j.bmc.2014.04.013

実験手法

X-RAY DIFFRACTION (2.2 Å)