4O70

Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB

4O70 の概要

• エントリーDOI: 10.2210/pdb4o70/pdb
• 関連するPDBエントリー: 4O71 4O72 4O73 4O74 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F
• 分子名称: Bromodomain-containing protein 4, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31763.65

構造登録者

Ember, S.W.,Zhu, J.-Y.,Watts, C.,Schonbrunn, E. (登録日: 2013-12-24, 公開日: 2014-03-05, 最終更新日: 2023-09-20)

• 主引用文献: Ember, S.W.,Zhu, J.Y.,Olesen, S.H.,Martin, M.P.,Becker, A.,Berndt, N.,Georg, G.I.,Schonbrunn, E.; Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.; Acs Chem.Biol., 9:1160-1171, 2014; PubMed: 24568369; DOI: 10.1021/cb500072z

実験手法

X-RAY DIFFRACTION (1.55 Å)