4O4G
Crystal Structure of HIV-1 Reverse Transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ527), a non-nucleoside inhibitor
Summary for 4O4G
Entry DOI | 10.2210/pdb4o4g/pdb |
Related | 1S9E 2ZD1 3M8P 4KKO 4O44 |
Descriptor | HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 4-({4-[(2,4,6-trimethylphenyl)amino]-1,3,5-triazin-2-yl}amino)benzonitrile, ... (4 entities in total) |
Functional Keywords | polymerase, rnase, reverse transcription, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 BH10 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114359.11 |
Authors | Mislak, A.C.,Frey, K.M. (deposition date: 2013-12-18, release date: 2014-11-05, Last modification date: 2023-09-20) |
Primary citation | Mislak, A.C.,Frey, K.M.,Bollini, M.,Jorgensen, W.L.,Anderson, K.S. A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. Biochim.Biophys.Acta, 1840:2203-2211, 2014 Cited by PubMed: 24726448DOI: 10.1016/j.bbagen.2014.04.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.712 Å) |
Structure validation
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