4O2P

Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine

4O2P の概要

• エントリーDOI: 10.2210/pdb4o2p/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, 1-[(2R)-2-chloro-2-phenylethyl]-6-{[2-(morpholin-4-yl)ethyl]sulfanyl}-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: pyrazolo-pyrimidine ligand, type i, dfg-in, tyrosine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Cell membrane : P00523
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66443.37

構造登録者

Richters, A.,Rauh, D. (登録日: 2013-12-17, 公開日: 2015-03-04, 最終更新日: 2023-09-20)

• 主引用文献: Tintori, C.,Fallacara, A.L.,Radi, M.,Zamperini, C.,Dreassi, E.,Crespan, E.,Maga, G.,Schenone, S.,Musumeci, F.,Brullo, C.,Richters, A.,Gasparrini, F.,Angelucci, A.,Festuccia, C.,Delle Monache, S.,Rauh, D.,Botta, M.; Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma.; J.Med.Chem., 58:347-361, 2015; PubMed: 25469771; DOI: 10.1021/jm5013159

実験手法

X-RAY DIFFRACTION (2.1 Å)