4O13

The crystal structure of NAMPT in complex with GNE-618

Summary for 4O13

• Entry DOI: 10.2210/pdb4o13/pdb
• Related: 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28
• Descriptor: Nicotinamide phosphoribosyltransferase, N-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}benzyl)-2H-pyrazolo[3,4-b]pyridine-5-carboxamide, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P43490
• Total number of polymer chains: 2
• Total formula weight: 115682.04

Authors

Oh, A.,Coons, M.,Brillantes, B.,Wang, W. (deposition date: 2013-12-15, release date: 2014-10-22, Last modification date: 2024-02-28)

• Primary citation: Wang, W.,Elkins, K.,Oh, A.,Ho, Y.C.,Wu, J.,Li, H.,Xiao, Y.,Kwong, M.,Coons, M.,Brillantes, B.,Cheng, E.,Crocker, L.,Dragovich, P.S.,Sampath, D.,Zheng, X.,Bair, K.W.,O'Brien, T.,Belmont, L.D.; Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.; Plos One, 9:e109366-e109366, 2014; PubMed: 25285661; DOI: 10.1371/journal.pone.0109366

Experimental method

X-RAY DIFFRACTION (1.75 Å)