4O0J
HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid
Summary for 4O0J
Entry DOI | 10.2210/pdb4o0j/pdb |
Related | 1ITG 4O55 4O5B |
Descriptor | Integrase, (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hiv integrase, ccd, dde motif, allosteric inhibitor, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497 |
Total number of polymer chains | 1 |
Total formula weight | 18892.62 |
Authors | Feng, L.,Kvaratskhelia, M. (deposition date: 2013-12-13, release date: 2014-07-02, Last modification date: 2017-11-22) |
Primary citation | Sharma, A.,Slaughter, A.,Jena, N.,Feng, L.,Kessl, J.J.,Fadel, H.J.,Malani, N.,Male, F.,Wu, L.,Poeschla, E.,Bushman, F.D.,Fuchs, J.R.,Kvaratskhelia, M. A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase. Plos Pathog., 10:e1004171-e1004171, 2014 Cited by PubMed: 24874515DOI: 10.1371/journal.ppat.1004171 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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