4O0J

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid

4O0J の概要

• エントリーDOI: 10.2210/pdb4o0j/pdb
• 関連するPDBエントリー: 1ITG 4O55 4O5B
• 分子名称: Integrase, (2S)-tert-butoxy[4-(4-chlorophenyl)-6-(3,4-dimethylphenyl)-2,5-dimethylpyridin-3-yl]ethanoic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hiv integrase, ccd, dde motif, allosteric inhibitor, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18892.62

構造登録者

Feng, L.,Kvaratskhelia, M. (登録日: 2013-12-13, 公開日: 2014-07-02, 最終更新日: 2017-11-22)

• 主引用文献: Sharma, A.,Slaughter, A.,Jena, N.,Feng, L.,Kessl, J.J.,Fadel, H.J.,Malani, N.,Male, F.,Wu, L.,Poeschla, E.,Bushman, F.D.,Fuchs, J.R.,Kvaratskhelia, M.; A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase.; Plos Pathog., 10:e1004171-e1004171, 2014; PubMed: 24874515; DOI: 10.1371/journal.ppat.1004171

実験手法

X-RAY DIFFRACTION (2.05 Å)