4O0A

Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions

4O0A の概要

• エントリーDOI: 10.2210/pdb4o0a/pdb
• 関連するPDBエントリー: 4luo 4luv 4luz 4lwc 4lwi
• 分子名称: Replication protein A 70 kDa DNA-binding subunit, 5-{4-[({[4-(5-carboxyfuran-2-yl)-2-chlorophenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid (3 entities in total)
• 機能のキーワード: ob-fold, protein-protein interaction, dna binding protein-inhibitor complex, dna binding protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14124.62

構造登録者

Feldkamp, M.D.,Frank, A.O.,Kennedy, J.P.,Waterson, A.G.,Olejniczak, E.T.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (登録日: 2013-12-13, 公開日: 2014-01-08, 最終更新日: 2023-09-20)

• 主引用文献: Frank, A.O.,Feldkamp, M.D.,Kennedy, J.P.,Waterson, A.G.,Pelz, N.F.,Patrone, J.D.,Vangamudi, B.,Camper, D.V.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.; Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.; J. Med. Chem., 56:9242-9250, 2013; PubMed: 24147804; DOI: 10.1021/jm401333u

実験手法

X-RAY DIFFRACTION (1.2 Å)