4NYB

Crystal structure of the E. coli thiM riboswitch in complex with (4-(1,2,3-thiadiazol-4-yl)phenyl)methanamine

Summary for 4NYB

Entry DOI	10.2210/pdb4nyb/pdb
Related	4NYA 4NYC 4NYD 4NYG
Descriptor	thiM TPP riboswitch, 1-[4-(1,2,3-thiadiazol-4-yl)phenyl]methanamine, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	fragment-based drug discovery, riboswitch, rna
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	27490.65
Authors	Warner, K.D.,Homan, P.,Weeks, K.M.,Smith, A.G.,Abell, C.,Ferre-D'Amare, A.R. (deposition date: 2013-12-10, release date: 2014-06-04, Last modification date: 2023-09-20)
Primary citation	Warner, K.D.,Homan, P.,Weeks, K.M.,Smith, A.G.,Abell, C.,Ferre-D'Amare, A.R. Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically. Chem.Biol., 21:591-595, 2014 Cited by PubMed: 24768306 DOI: 10.1016/j.chembiol.2014.03.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation