4NW3
Crystal structure of MLL CXXC domain in complex with a CpG DNA
Summary for 4NW3
Entry DOI | 10.2210/pdb4nw3/pdb |
Descriptor | Histone-lysine N-methyltransferase 2A, 5'-D(*GP*CP*CP*AP*TP*CP*GP*AP*TP*GP*GP*C)-3', ZINC ION (3 entities in total) |
Functional Keywords | histone-lysine n-methyltransferase, cpg island, cg island, structural genomics consortium, sgc, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus . MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164 |
Total number of polymer chains | 3 |
Total formula weight | 16262.92 |
Authors | Bian, C.,Tempel, W.,Chao, X.,Walker, J.R.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2013-12-05, release date: 2014-04-23, Last modification date: 2023-09-20) |
Primary citation | Xu, C.,Liu, K.,Lei, M.,Yang, A.,Li, Y.,Hughes, T.R.,Min, J. DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Structure, 26:85-95.e3, 2018 Cited by PubMed: 29276034DOI: 10.1016/j.str.2017.11.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.82 Å) |
Structure validation
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