4NUX

Structure of receptor A

Summary for 4NUX

• Entry DOI: 10.2210/pdb4nux/pdb
• Descriptor: Interleukin-17 receptor A (2 entities in total)
• Functional Keywords: sefir domain, immune system, cytokine, receptor, autoimmune inflammatory
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Membrane; Single-pass type I membrane protein (By similarity). Isoform 2: Secreted: Q96F46
• Total number of polymer chains: 1
• Total formula weight: 24771.56

Authors

Zhang, B.,Han, Y.,Deng, J. (deposition date: 2013-12-04, release date: 2014-05-14, Last modification date: 2024-02-28)

• Primary citation: Zhang, B.,Liu, C.,Qian, W.,Han, Y.,Li, X.,Deng, J.; Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved alpha-helix for Act1 binding and IL-17 signaling.; Acta Crystallogr.,Sect.D, 70:1476-1483, 2014; PubMed: 24816115; DOI: 10.1107/S1399004714005227

Experimental method

X-RAY DIFFRACTION (2.295 Å)