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4NUE

Crystal structure of the first bromodomain of human BRD4 in complex with MS267 inhibitor

Summary for 4NUE
Entry DOI10.2210/pdb4nue/pdb
Related4NUC 4NUD
DescriptorBromodomain-containing protein 4, 4-[(E)-(2-amino-4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstranscription factor, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O60885
Total number of polymer chains1
Total formula weight15558.90
Authors
Plotnikov, A.N.,Joshua, J.,Zhou, M.-M. (deposition date: 2013-12-03, release date: 2014-04-02, Last modification date: 2023-09-20)
Primary citationZhang, G.,Plotnikov, A.N.,Rusinova, E.,Shen, T.,Morohashi, K.,Joshua, J.,Zeng, L.,Mujtaba, S.,Ohlmeyer, M.,Zhou, M.-M.
Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
J.Med.Chem., 56:9251-9264, 2013
Cited by
PubMed: 24144283
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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