4NUC
Crystal structure of the first bromodomain of human BRD4 in complex with MS435 inhibitor
Summary for 4NUC
Entry DOI | 10.2210/pdb4nuc/pdb |
Related | 4NUD 4NUE |
Descriptor | Bromodomain-containing protein 4, 4-[(E)-(4-hydroxy-3,5-dimethylphenyl)diazenyl]-N-(pyridin-2-yl)benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | transcription factor, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15543.88 |
Authors | Plotnikov, A.N.,Joshua, J.,Zhou, M.-M. (deposition date: 2013-12-03, release date: 2014-04-02, Last modification date: 2023-09-20) |
Primary citation | Zhang, G.,Plotnikov, A.N.,Rusinova, E.,Shen, T.,Morohashi, K.,Joshua, J.,Zeng, L.,Mujtaba, S.,Ohlmeyer, M.,Zhou, M.-M. Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains J.Med.Chem., 56:9251-9264, 2013 Cited by PubMed: 24144283PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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