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4NRO

Crystal structure of human ALKBH5 in complex with alpha-ketoglutarate

Summary for 4NRO
Entry DOI10.2210/pdb4nro/pdb
Related4NRM 4NRP 4NRQ
DescriptorRNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ... (4 entities in total)
Functional Keywordsalkbh5, 6-methyl adenosine, protein/dna interaction, human dioxygenase, metal-binding, nucleus, demethylation, rna repair, oxidoreductase
Biological sourceHomo sapiens
Cellular locationNucleus speckle : Q6P6C2
Total number of polymer chains1
Total formula weight26586.16
Authors
Feng, C.,Chen, Z.,Liu, Y. (deposition date: 2013-11-27, release date: 2014-03-19, Last modification date: 2023-11-08)
Primary citationFeng, C.,Liu, Y.,Wang, G.,Deng, Z.,Zhang, Q.,Wu, W.,Tong, Y.,Cheng, C.,Chen, Z.
Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition
J.Biol.Chem., 289:11571-11583, 2014
Cited by
PubMed: 24616105
DOI: 10.1074/jbc.M113.546168
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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