4NRB

Crystal Structure of the bromodomain of human BAZ2B in complex with compound-1 N01197

4NRB の概要

• エントリーDOI: 10.2210/pdb4nrb/pdb
• 関連するPDBエントリー: 4NR9 4NRA 4NRC
• 分子名称: Bromodomain adjacent to zinc finger domain protein 2B, N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: sgc, structural genomics consortium, transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (Potential): Q9UIF8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13916.00

構造登録者

Muniz, J.R.C.,Felletar, I.,Chaikuad, A.,Filippakopoulos, P.,Ferguson, F.M.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Ciulli, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2013-11-26, 公開日: 2013-12-25, 最終更新日: 2023-09-20)

• 主引用文献: Ferguson, F.M.,Fedorov, O.,Chaikuad, A.,Philpott, M.,Muniz, J.R.,Felletar, I.,von Delft, F.,Heightman, T.,Knapp, S.,Abell, C.,Ciulli, A.; Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.; J.Med.Chem., 56:10183-10187, 2013; PubMed: 24304323; DOI: 10.1021/jm401582c

実験手法

X-RAY DIFFRACTION (2.08 Å)