4NRA
Crystal Structure of the bromodomain of human BAZ2B in complex with compound-6 E11322
Summary for 4NRA
Entry DOI | 10.2210/pdb4nra/pdb |
Related | 4NR9 4NRB 4NRC |
Descriptor | Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 1-(8-chloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)ethanone, ... (4 entities in total) |
Functional Keywords | sgc, structural genomics consortium, transcription, bromodomain, acetylated lysine binding protein, kiaa1476, walp4 |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Potential): Q9UIF8 |
Total number of polymer chains | 1 |
Total formula weight | 14177.70 |
Authors | Chaikuad, A.,Felletar, I.,Ferguson, F.M.,Filippakopoulos, P.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-25, Last modification date: 2023-09-20) |
Primary citation | Ferguson, F.M.,Fedorov, O.,Chaikuad, A.,Philpott, M.,Muniz, J.R.,Felletar, I.,von Delft, F.,Heightman, T.,Knapp, S.,Abell, C.,Ciulli, A. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J.Med.Chem., 56:10183-10187, 2013 Cited by PubMed: 24304323DOI: 10.1021/jm401582c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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