4NR7

Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand

Summary for 4NR7

• Entry DOI: 10.2210/pdb4nr7/pdb
• Descriptor: CREB-binding protein, 1,2-ETHANEDIOL, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, ... (4 entities in total)
• Functional Keywords: structural genomics consortium, sgc, chemical tool, small molecule inhibitor, transcription, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 1
• Total formula weight: 14918.59

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Krojer, T.,Nowak, R.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-26, release date: 2013-12-18, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Krojer, T.,Nowak, R.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (1.2 Å)