4NR7
Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand
4NR7 の概要
エントリーDOI | 10.2210/pdb4nr7/pdb |
分子名称 | CREB-binding protein, 1,2-ETHANEDIOL, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, ... (4 entities in total) |
機能のキーワード | structural genomics consortium, sgc, chemical tool, small molecule inhibitor, transcription, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: Q92793 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 14918.59 |
構造登録者 | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Krojer, T.,Nowak, R.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2013-11-26, 公開日: 2013-12-18, 最終更新日: 2023-09-20) |
主引用文献 | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hay, D.,Fedorov, O.,Martin, S.,Krojer, T.,Nowak, R.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand To be Published, |
実験手法 | X-RAY DIFFRACTION (1.2 Å) |
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