4NQM

Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand

Summary for 4NQM

• Entry DOI: 10.2210/pdb4nqm/pdb
• Related: 4NQN
• Descriptor: Bromodomain-containing protein 4, 2-chloro-N-[5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-(morpholin-4-yl)phenyl]benzenesulfonamide, SUCCINIC ACID, ... (4 entities in total)
• Functional Keywords: structural genomics consortium, sgc, bromodomain, inhibition, transcription, small molecule inhibitor, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15752.48

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-11-25, release date: 2013-12-18, Last modification date: 2024-02-28)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand; To be Published,

Experimental method

X-RAY DIFFRACTION (1.58 Å)