4NQM

Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand

4NQM の概要

• エントリーDOI: 10.2210/pdb4nqm/pdb
• 関連するPDBエントリー: 4NQN
• 分子名称: Bromodomain-containing protein 4, 2-chloro-N-[5-(3-methyl[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-2-(morpholin-4-yl)phenyl]benzenesulfonamide, SUCCINIC ACID, ... (4 entities in total)
• 機能のキーワード: structural genomics consortium, sgc, bromodomain, inhibition, transcription, small molecule inhibitor, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15752.48

構造登録者

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2013-11-25, 公開日: 2013-12-18, 最終更新日: 2024-02-28)

• 主引用文献: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal Structure of the first bromodomain of human BRD4 in complex with a triazolo-phthalazine ligand; To be Published,

実験手法

X-RAY DIFFRACTION (1.58 Å)