4NLR

Poliovirus Polymerase - C290S Loop Mutant

4NLR の概要

• エントリーDOI: 10.2210/pdb4nlr/pdb
• 関連するPDBエントリー: 4NLO 4NLP 4NLQ 4NLS 4NLT 4NLU 4NLV 4NLW 4NLX 4NLY
• 分子名称: RNA-directed RNA polymerase 3D-POL, ACETIC ACID, PENTAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: polymerase, rna dependent rna polymerase, rdrp, virus, viral protein, hydrolase
• 由来する生物種: Human poliovirus 1
• 細胞内の位置: Capsid protein VP0: Virion. Capsid protein VP4: Virion. Capsid protein VP2: Virion. Capsid protein VP3: Virion. Capsid protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3AB: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Viral protein genome-linked: Virion. Protease 3C: Host cytoplasm. Protein 3CD: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03300
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53727.67

構造登録者

Sholders, A.J.,Peersen, O.B. (登録日: 2013-11-14, 公開日: 2014-01-22, 最終更新日: 2023-09-20)

• 主引用文献: Sholders, A.J.,Peersen, O.B.; Distinct conformations of a putative translocation element in poliovirus polymerase.; J.Mol.Biol., 426:1407-1419, 2014; PubMed: 24424421; DOI: 10.1016/j.jmb.2013.12.031

実験手法

X-RAY DIFFRACTION (2 Å)