4NLK
Structure of human DNA polymerase beta complexed with 8BrG in the template base-paired with incoming non-hydrolyzable CTP
Summary for 4NLK
Entry DOI | 10.2210/pdb4nlk/pdb |
Related | 1BPX 3ISB 4NLN 4NLZ 4NM1 4NM2 |
Descriptor | 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... (8 entities in total) |
Functional Keywords | dna binding, helix-turn-helix motif, polymerase fold, nucleotidyl transferase, nucleus, transferase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P06746 |
Total number of polymer chains | 4 |
Total formula weight | 47641.64 |
Authors | Koag, M.-C.,Min, K.,Monzingo, A.F.,Lee, S. (deposition date: 2013-11-14, release date: 2014-01-22, Last modification date: 2024-02-28) |
Primary citation | Koag, M.C.,Min, K.,Lee, S. Structural basis for promutagenicity of 8-halogenated Guanine. J.Biol.Chem., 289:6289-6298, 2014 Cited by PubMed: 24425881DOI: 10.1074/jbc.M113.537803 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.494 Å) |
Structure validation
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