4NJ3
Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor
Summary for 4NJ3
Entry DOI | 10.2210/pdb4nj3/pdb |
Descriptor | Cyclin-dependent kinase 2, 6-(3-chlorophenyl)-2-{[(2S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid (3 entities in total) |
Functional Keywords | cell cycle, inhibition, cyclin-dependent kinase, cancer, atp-binding, cell division, mitosis, nucleotide-binding, phosphorylation, transferase, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34539.44 |
Authors | Fischmann, T.O.,Hruza, A.W. (deposition date: 2013-11-08, release date: 2013-11-27, Last modification date: 2014-01-08) |
Primary citation | Deng, Y.,Shipps, G.W.,Zhao, L.,Siddiqui, M.A.,Popovici-Muller, J.,Curran, P.J.,Duca, J.S.,Hruza, A.W.,Fischmann, T.O.,Madison, V.S.,Zhang, R.,McNemar, C.W.,Mayhood, T.W.,Syto, R.,Annis, A.,Kirschmeier, P.,Lees, E.M.,Parry, D.A.,Windsor, W.T. Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Bioorg.Med.Chem.Lett., 24:199-203, 2014 Cited by PubMed: 24332088DOI: 10.1016/j.bmcl.2013.11.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.848 Å) |
Structure validation
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